Status:
COMPLETED
Pre-hospital Administration of Thrombolytic Therapy With Urgent Culprit Artery Revascularization
Lead Sponsor:
The University of Texas Health Science Center, Houston
Conditions:
Heart Disease
Myocardial Infarction
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The PATCAR study has been designed to test the hypothesis that the strategy of pre-hospital use of a "clot busting" (thrombolytic) drug followed with emergent heart catheterization including stenting ...
Detailed Description
To demonstrate feasibility of the project in a pilot trial we plan to enroll up to 500 patients to pre-hospital thrombolysis/clot busting followed by emergent catheterization and stenting of the probl...
Eligibility Criteria
Inclusion
- Ischemic discomfort (squeezing, crushing, or pressure, sub-sternal, unrelated to breathing or movement), epigastric discomfort or pre-syncopal symptoms with diaphoresis, lasting \> 30 minutes.
- ST elevation \> 0.1 mV in 2 or more contiguous limb leads or \> 0.2 mV in 2 or more contiguous pre-cordial leads.
- Less than 6 hours after onset of sustained chest pain.
- Age 18 years or older.
Exclusion
- Chest pain described as ripping or tearing, radiating to the back and/or down the leg, and/or systolic blood pressure \> 15 mmHg difference in each arm.
- Suspected cocaine or amphetamine use within previous 3 days.
- Known or suspected pregnancy.
- Cardiac arrest requiring intubation.
- Cardiac arrest requiring greater than 20 minutes CPR.
- Coronary intervention (PTCA/stent/CABG) within previous 4 weeks.
Key Trial Info
Start Date :
September 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2009
Estimated Enrollment :
390 Patients enrolled
Trial Details
Trial ID
NCT00178620
Start Date
September 1 2003
End Date
December 1 2009
Last Update
September 6 2023
Active Locations (1)
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1
Memorial Hermann Hospital / The University of Texas HSC
Houston, Texas, United States, 77030