Status:
ACTIVE_NOT_RECRUITING
Proteomics of Brain Trauma-associated Elevated Intracranial Pressure (ICP)
Lead Sponsor:
The University of Texas Health Science Center, Houston
Collaborating Sponsors:
TIRR/Mission Connect
The Center for Clinical and Translational Sciences (CCTS) Clinical Research Unit at The University of Texas Health Science Center at Houston
Conditions:
Brain Injuries, Traumatic
Traumatic Brain Injury
Eligibility:
All Genders
14-65 years
Brief Summary
The specific aim of this research is to determine if the blood from brain-injured patients contains reproducible protein markers that appear prior to elevations in intracranial pressure (ICP).
Detailed Description
One of the major causes of death following brain trauma is increased intracranial pressure (ICP). Currently, there are no effective ways to predict if the ICP of a patient will reach uncontrollable le...
Eligibility Criteria
Inclusion
- 14-65 years old
- Non-penetrating brain injury
- ICP monitor or
- Healthy volunteer or
- The orthopedic injury cohort will include patients admitted to the ED able to provide informed consent with the following:
- Fracture confirmed radiographically
- No head trauma
- No other known inflammatory process or infection
- No history of neurological or psychiatric disorders or alcohol or drug dependency.
- or The mild TBI patients will be defined as those experiencing,
- Non-penetrating head trauma manifesting one or more of the following:
- Loss of consciousness
- Post-traumatic amnesia
- Altered mental status
- Focal neurologic deficits, seizure
- GCS\> 12
- No abnormalities on CT other than contusion
- No operative Lesions
- Length of hospital stay \< 48 hrs
- No other known inflammatory process or infection
- No history of neurological or psychiatric disorders or alcohol or drug dependency
Exclusion
- Inability to obtain informed consent
Key Trial Info
Start Date :
July 1 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2030
Estimated Enrollment :
260 Patients enrolled
Trial Details
Trial ID
NCT00178659
Start Date
July 1 2004
End Date
December 1 2030
Last Update
August 7 2025
Active Locations (1)
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1
The University of Texas, Houston
Houston, Texas, United States, 77030