Status:
COMPLETED
The Autonomic Nervous System and Obesity
Lead Sponsor:
Vanderbilt University
Conditions:
OBESITY
HYPERTENSION
Eligibility:
All Genders
18-80 years
Phase:
PHASE1
Brief Summary
In its simplest terms, obesity is the results of a positive balance between food intake and energy expenditure (EE). I.e., we take in more energy, in the form of food, than we expend, e.g., by exercis...
Detailed Description
The rationale for this study is that even small alterations to energy metabolism can significantly change energy balance and body weight in the long term. We will test the hypothesis that the sympathe...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Healthy normal (BMI \<= 25 Kg/m2), obese (BMI between 30 and 40)volunteers, lean hypertensive (BMI 20-28 Kg/m2), and obese hypertensive (BMI between 30 and 40)
- Ages 18-60
- Patients with pure autonomic failure and multiple system atrophy ages 18-80, referred to our service for the diagnosis and treatment of their condition, and their age sex-matched sedentary, healthy controls ages 18-80
- Exclusion criteria:
- All medical students
- Pregnant women
- Heart failure, symptomatic coronary artery disease, liver impairment, history of stroke or myocardial infarction, glaucoma
- History of serious allergies or asthma
- Subjects using beta-blockers
Exclusion
Key Trial Info
Start Date :
April 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2017
Estimated Enrollment :
128 Patients enrolled
Trial Details
Trial ID
NCT00179023
Start Date
April 1 2003
End Date
January 1 2017
Last Update
March 1 2018
Active Locations (1)
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1
Vanderbilt University
Nashville, Tennessee, United States, 37232