Status:
WITHDRAWN
Molecular Mechanism of Asthma
Lead Sponsor:
Imperial College London
Conditions:
Asthma
Eligibility:
All Genders
21-55 years
Phase:
NA
Brief Summary
The aim of this study is to investigate the mechanisms whereby lung function is decreased in asthma and sensitivity to treatment. The hypothesis is that in diseases such as asthma, inflammatory cells ...
Detailed Description
We aim to investigate these separate cell types in the blood of subjects with asthma and identify which genes are more highly expressed when compared to cells obtained from patients without asthma. We...
Eligibility Criteria
Inclusion
- Asthmatic Patients
- Stable asthmatics on beta-2 agonist alone not using more than 4 puffs per day
- Atopic as defined by positive skin prick tests to at least 2 common aeroallergens
- PC20 methacholine of \< 4 mg /ml
- Increase in FEV1 \> 15% following beta-2 agonist inhalation, either at the time of study or previously documented
- Age 21-55 years of both sexes (females will be taking adequate contraceptive measures)
- Non-smokers
- Normal chest x-ray (CXR) and electrocardiogram (ECG) within the last 6 months.
- Healthy Non-Asthmatic Subjects
- All normal volunteers will meet the following criteria:
- Age 21-70 years of both sexes (females will be taking adequate contraceptive measures)
- No history of respiratory or allergic disease e.g. PC20 methacholine of \> 64mg/ml and negative skin prick tests
- Non-atopic with negative skin prick tests to common aeroallergens
- Normal baseline spirometry as predicted for age, sex and height.
- Non-smokers
- Not taking regular medication
- No upper respiratory tract infection within the last 6 weeks
Exclusion
- Subjects will not be included in this study if they meet any of the following exclusion criteria:
- Clinically significant findings in the medical history or on physical examination other than those of asthma in the asthma group.
- Lung function FEV1 \<30%
- Pregnant women or mothers who are breastfeeding.
- Patients who smoke
- Upper respiratory infection within the last 4 weeks
- Allergy to local anaesthetic
- Subjects who are unable to give informed consent.
Key Trial Info
Start Date :
December 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2007
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00180726
Start Date
December 1 2003
End Date
July 1 2007
Last Update
May 9 2019
Active Locations (1)
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1
Airway Disease, NHLI, Imperial College
London, United Kingdom, SW3 6LY