Status:
COMPLETED
Comparison of High-Dose Methotrexate (HDM) Plus Doxorubicin to HDM Plus Etoposide-Ifosfamide in Osteosarcoma Children
Lead Sponsor:
Gustave Roussy, Cancer Campus, Grand Paris
Conditions:
Osteosarcoma
Localised High Grade Osteosarcoma of the Limbs
Eligibility:
All Genders
Up to 20 years
Phase:
PHASE3
Brief Summary
The purpose of this study is to compare two preoperative chemotherapy regimens based on high-dose methotrexate courses given alternately either with doxorubicin or with etoposide-ifosfamide.
Eligibility Criteria
Inclusion
- non metastatic limb osteosarcoma,
- age less than 20 years,
- biopsy proven high-grade osteosarcoma,
- no previous treatment,
- no contraindication to chemotherapy
- no previous malignancy,
- Written informed consent.
Exclusion
- juxta-cortical sarcoma and microcellular anaplastic sarcoma,
- previous anticancer treatment
- contraindication to chemotherapy
- previous malignancy,
Key Trial Info
Start Date :
June 1 1994
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
226 Patients enrolled
Trial Details
Trial ID
NCT00180908
Start Date
June 1 1994
Last Update
September 16 2005
Active Locations (1)
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1
Institut Gustave-Roussy
Villejuif, France, 94805