Status:
COMPLETED
Airway Clearance for Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
Centers for Medicare and Medicaid Services
Hill-Rom
Conditions:
COPD
Chronic Bronchitis
Eligibility:
All Genders
45-85 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to show that one form of mechanical airway clearance techniques, High Frequency Chest Wall Oscillation (HFCWO)using a pneumatic vest, will diminish exacerbations of COPD w...
Detailed Description
Approximately 60 to 70% of people with COPD have chronic cough and phlegm, the cardinal symptoms of chronic bronchitis or chronic mucus hypersecretion (CMH). Once thought to be a relatively benign con...
Eligibility Criteria
Inclusion
- Physician Diagnosis of COPD,chronic bronchitis and/or emphysema
- Forced Expiratory Volume in 1 second (FEV1)/ Forced Vital Capacity (FVC) \< or = 70%
- FEV1 \< or = 65%
- Current or former smoker \> or = 20 pack years
- History of 1 or more COPD exacerbations in past 6 months necessitation hospitalization, Emergency Department (ED) visit, antibiotic or steroid prescription
Exclusion
- Other lung diseases
- Co-morbid illnesses such as cancer, liver disease, cardiomyopathy
- Recent chest wall or abdominal trauma or surgery that would preclude using the vest
Key Trial Info
Start Date :
May 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2007
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00181207
Start Date
May 1 2004
End Date
December 1 2007
Last Update
October 19 2018
Active Locations (1)
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1
Johns Hopkins Asthma and Allergy Center
Baltimore, Maryland, United States, 21224