Status:
TERMINATED
Macrolides to Prevent Exacerbations of Asthma and Chronic Obstructive Pulmonary Disease
Lead Sponsor:
Johns Hopkins University
Conditions:
Asthma
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to determine whether macrolide therapy is effective in treating patients hospitalized with asthma exacerbations or chronic obstructive pulmonary disease (COPD)exacerbation...
Detailed Description
Asthma and chronic obstructive pulmonary disease (COPD) are the two most common obstructive lung diseases. Chronic airway inflammation and episodic worsening of respiratory symptoms and airflow obstru...
Eligibility Criteria
Inclusion
- Physician-diagnosis of asthma, COPD exacerbation, or undifferentiated asthma/COPD exacerbation
- Admitted to the inpatient medical service at Johns Hopkins Hospital or Johns Hopkins Bayview Medical Center
- Evidence of airflow obstruction on spirometry (FEV1/FVC\<70%)
- Age 18 years or older
Exclusion
- History of allergy or other contraindication to macrolides (azithromycin, erythromycin, clarithromycin)
- Treatment with any macrolide in the 4 weeks prior to study entry
- Elevated AST or ALT (2 or more times the upper limit of normal) on current admission
- Elevated alkaline phosphatase (\>1.25 times the upper limit of normal) on current admission
- Elevated total serum bilirubin (more than upper limit of normal) on current admission
- Previous participation in this study
- Patients prescribed digoxin (azithromycin may increase digoxin levels)
- Patients prescribed warfarin (azithromycin may increase INR in patients on warfarin)
- Patients prescribed pimozide (azithromycin may increase risk of arrhythmias)
- Patient unable to provide consent (e.g., language difficulty or history of dementia)
- Patient to be discharged to a location other than home (e.g., other hospital, long-term care facility)
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
End Date :
July 1 2006
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT00181272
Start Date
September 1 2005
End Date
July 1 2006
Last Update
May 13 2013
Active Locations (1)
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1
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21205