Status:
COMPLETED
Effectiveness of D-Cycloserine as an Aid to Enhance Learning for Individuals With OCD Receiving Behavior Therapy
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
Hartford Hospital
Conditions:
Obsessive-Compulsive Disorder
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
This study will assess the effectiveness of Seromycin (D-cycloserine) in enhancing the positive effects of behavior therapy for people with Obsessive-Compulsive Disorder (OCD).
Detailed Description
We hope to enroll 50 subjects in a double-blind, placebo-controlled study of D-cycloserine augmentation of behavior therapy for Obsessive-Compulsive Disorder. All subjects will undergo a pre-treatment...
Eligibility Criteria
Inclusion
- Structured Clinical Interview for DSM-IV (SCID) diagnosis of Obsessive Compulsive Disorder
- Score of greater than 16 on the Yale-Brown Obsessive Compulsive Scale
- Negative urinary beta-Human Chorionic Gonadotropin (hCG) test
Exclusion
- Currently taking or have taken an unstable dose of psychotropic medications within 2 months prior to enrollment
- Currently taking medications that may interfere with the study medication
- History of seizure disorder or other serious medical illnesses (e.g., cardiovascular, liver, kidney, respiratory, endocrine, neurologic, or blood-related disease)
- Current diagnosis of tuberculosis
- Other psychiatric diagnoses (e.g., alcohol dependence, bipolar disorder, psychosis, organic mental disorder, or development disorder) that are of greater concern than the obsessive-compulsive disorder diagnosis
- Currently taking medications that may lower seizure threshold (e.g., including clozapine, pethidine, and the following antibiotics in high dosage: penicillins, cephalosporins, amphotericin, and imipenem)
- Poses a serious suicidal or homicidal threat
- Currently undergoing psychotherapy
- Failure to benefit from ten or more sessions of previous Exposure and Response Prevention (ERP) treatment
- Pregnant or breastfeeding
Key Trial Info
Start Date :
November 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
33 Patients enrolled
Trial Details
Trial ID
NCT00182000
Start Date
November 1 2003
Last Update
July 16 2012
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