Status:
TERMINATED
Study of Noscapine for Patients With Low Grade Non Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia Refractory to Chemotherapy
Lead Sponsor:
University of Southern California
Conditions:
Non-Hodgkin's Lymphoma
Chronic Lymphocytic Leukemia
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
This study is for patients with non-hodgkin's lymphoma or chronic lymphocytic leukemia, which has failed to shrink or has returned after previous treatment with chemotherapy. The purpose of this study...
Eligibility Criteria
Inclusion
- Patients with low grade NHL (follicular lymphoma, small cell lymphocytic lymphoma, marginal cell lymphoma, monocytoid B-cell lymphoma, MALT lymphoma, plasmacytoid lymphocytic lymphoma) or chronic lymphocytic leukemia who have demonstrated chemotherapy resistance (have not achieved CR,CRu, PR)or who have relapsed at any time following a response (CR, CRu, PR) after at least one therapy regimen, including chemotherapy, Rituximab, or high dose chemotherapy with stem cell rescue.
- Karnofsky performance status 60 % or greater.
- Creatinine less or equal to 2.0 mg/dl, bilirubin less or equal to 2.0 mg/dl, SGPT/SGOT less or equal to 4 x upper normal range
Exclusion
- Patients with unconfirmed complete response(CRu)after last treatment and who currently remain in CRu.
- Pregnant or lactating women.
- Disease-specific treatment less than 1 month prior to starting this study.
- CNS disease.
- HIV-positive patients.
- Other cancer, except basal cell or squamous cell cancer of the skin or carcinoma in-situ of cervix.
Key Trial Info
Start Date :
March 1 2000
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2006
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00183950
Start Date
March 1 2000
End Date
December 1 2006
Last Update
May 22 2014
Active Locations (1)
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1
USC/Norris Comprehensive Cancer Center and Hospital
Los Angeles, California, United States, 90033