Status:
COMPLETED
Botulinum Toxin Injection in Neck Muscles in Cervicogenic Headache
Lead Sponsor:
Norwegian University of Science and Technology
Conditions:
Cervicogenic Headache
Eligibility:
All Genders
18-70 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to investigate the effect and side-effects of injections with botulinum toxin in neck muscles in cervicogenic headache compared to injections with sodium water.
Detailed Description
Cervicogenic headache is a unilateral headache stemming from the neck. Usually, there are no pathological findings on x-ray or MRI of the neck. It is supposed that pain may stem from various structure...
Eligibility Criteria
Inclusion
- Headache strictly unilateral without side-shift
- Traits indicating involvement of neck structures, fulfilling at least 2 of the following:
- I. Reduced neck range of motion II. Typical headache can be elicited by palpation or pressure on muscles of the occiput or in the neck.
- III. Typical headache can be precipitated by certain neck movements or by adopting a certain position of the head.
- IV. There is a radiation of pain to the ipsilateral shoulder or arm.
- Positive effect of blockades. (In this study only a blockade of the greater occipital nerve will be applied).
- The condition has lasted for more than 1 year.
- The headache should be present more than 15 days a month, and the frequency should be based on a headache diary filled in the last month before inclusion.
Exclusion
- Cervical spinal stenosis, cervical disc herniation, or other neck pathology that should be treated surgically.
- Malignant disorder.
- Rheumatic disorder or other disorders which induces analgesic use.
- other clinically relevant disease (liver, kidney, endocrinological, metabolical, systemic, psychiatric).
- Frequent other headache type that cannot be distinguished from cervicogenic headache.
- Pending or ongoing litigation for head- or neck trauma.
Key Trial Info
Start Date :
May 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2009
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT00184197
Start Date
May 1 2005
End Date
December 1 2009
Last Update
March 13 2017
Active Locations (1)
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1
Dept. of Neurology and Clinical Neurophysiology, Norwegian Headache Centre
Trondheim, Norway, 7006