Status:
COMPLETED
Stromal Therapy of Osteodysplasia After Allogeneic Bone Marrow Transplantation
Lead Sponsor:
St. Jude Children's Research Hospital
Collaborating Sponsors:
Drexel University
Wayne State University
Conditions:
Osteodysplasia
Eligibility:
All Genders
Phase:
PHASE1
Brief Summary
Osteodysplasia or poorly formed bones, "brittle bones" is a genetic disease with no known proven treatments. Some forms of osteodysplasia may cause severe disability and even death. Eligible patients...
Detailed Description
* To determine whether these ex vivo expanded, gene marked marrow stromal cells will engraft in the recipient's bone, bone marrow, and/or skin. * To begin to investigate whether high proliferative mes...
Eligibility Criteria
Inclusion
- Patients with an appropriate genetic disorder who have had an allogeneic bone marrow transplant and currently maintain complete or mixed hematopoietic chimerism
- Patient must be \< or equal to 18Kg
Exclusion
- Presence of infection
- Presence of GVHD (graft versus host disease)or the need for prophylaxis
- Concurrent participation in any investigational study that could potentially confound the interpretation of the safety parameters being investigated in this study.
Key Trial Info
Start Date :
July 1 1999
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2008
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT00186914
Start Date
July 1 1999
End Date
January 1 2008
Last Update
March 4 2015
Active Locations (1)
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1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105