Status:
TERMINATED
Total Therapy Study XIV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia
Lead Sponsor:
St. Jude Children's Research Hospital
Conditions:
Acute Lymphoblastic Leukemia
Eligibility:
All Genders
Up to 18 years
Phase:
PHASE3
Brief Summary
The main purpose of this study is to find out if radiation to the central nervous system (CNS) can be safely omitted with early intensification of chemotherapy and chemotherapy given directly to the C...
Detailed Description
There are multiple secondary objectives in this trial: * To estimate the overall event-free survival of patients treated with risk-directed therapy * To identify the plasma methotrexate (MTX) concent...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Diagnosis of non-B-cell leukemia by immunophenotyping (e.g. T-cell, B-cell precursor, or acute undifferentiated leukemia)
- Ages less than or equal to 18 years of age
- One week or less of prior therapy, limited to glucocorticoids, vinca alkaloids, emergency radiation therapy to the mediastinum and one dose of intrathecal chemotherapy Exclusion Criteria
- Participants greater than 18 years of age
Exclusion
Key Trial Info
Start Date :
July 1 1998
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2002
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT00187005
Start Date
July 1 1998
End Date
July 1 2002
Last Update
March 30 2011
Active Locations (1)
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1
St.Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105