Status:
COMPLETED
A Study for Image-Guided Radiation Therapy in Pediatric Brain Tumors and Side Effects
Lead Sponsor:
St. Jude Children's Research Hospital
Conditions:
Central Nervous System Tumors
Brain Tumors
Eligibility:
All Genders
8-25 years
Phase:
PHASE2
Brief Summary
The purpose of the study was to determine if treating a limited volume of normal tissue surrounding the tumor or tumor bed using conformal radiation therapy would achieve similar rates of disease cont...
Detailed Description
Radiation therapy is commonly used to treat a variety of brain tumors in children including ependymoma, craniopharyngioma and low- and high-grade glioma. The ability of the therapy to control brain tu...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Age at time of irradiation is greater than or equal to 8 months and less than or equal to 25 years
- Histologically diagnosed craniopharyngioma, ependymoma, low-grade astrocytoma or high-grade glioma and radiographically diagnosed selected patients with craniopharyngioma and low-grade glioma.
- Adequate performance status, participant has an ECOG (Performance Status Score) of 0-2(0=Normal Activity; 1=Symptoms but Ambulatory; 2=Bedridden \<50% of time)
- Histologic type that requires only focal irradiation.
- No prior fractionated external beam irradiation
- Informed consent signed by patient, parent, or guardian.
Exclusion
Key Trial Info
Start Date :
June 1 1997
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2022
Estimated Enrollment :
361 Patients enrolled
Trial Details
Trial ID
NCT00187226
Start Date
June 1 1997
End Date
February 1 2022
Last Update
May 31 2023
Active Locations (1)
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1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105