Status:
COMPLETED
Organic Cation Transporter 1 (OCT1), on Response to Metformin in Healthy Subjects
Lead Sponsor:
University of California, San Francisco
Conditions:
Other Conditions That May Be A Focus of Clinical Attention
Eligibility:
All Genders
18-40 years
Phase:
PHASE4
Brief Summary
Specific Objectives: * To determine if individuals who carry a decreased or non-functional variant of OCT1 exhibit differences in the pharmacokinetics of metformin in comparison to individuals who ca...
Detailed Description
In the proposed studies, we will address two questions: •Do individuals who carry one of OCT1 variants with reduced or no function exhibit differences in the pharmacokinetics of metformin in comparis...
Eligibility Criteria
Inclusion
- Previous participation in the Study Of Pharmacogenetics In Ethnically Diverse Populations (SOPHIE) study.
- Between the ages of 18 and 40.
- Possess a specific OCT1 genotype.
Exclusion
- Taking any medications other than vitamins
- Individuals with anemia (hemoglobin \< 12 g/dL), an elevation in liver enzymes to higher than double the respective normal value, or elevated creatinine concentrations (males ≥ 1.5 mg/dL, females ≥ 1.4 mg/dL)
- Pregnant at time of study.
Key Trial Info
Start Date :
July 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2008
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00187681
Start Date
July 1 2003
End Date
March 1 2008
Last Update
January 8 2013
Active Locations (1)
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1
San Francisco General Hospital
San Francsico, California, United States, 94143