Status:
UNKNOWN
Insulin Cardioplegia for Poor Left Ventricular Function
Lead Sponsor:
University Health Network, Toronto
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Conditions:
Left Ventricular Dysfunction
Eligibility:
All Genders
Phase:
NA
Brief Summary
The purpose of this investigation is to develop a means to improve the recovery of cardiac metabolism and ventricular function following coronary artery bypass surgery (CABG) in patients with poor pre...
Detailed Description
Hypothesis Insulin added to blood cardioplegia will improve the results of Coronary Artery Bypass Graft by reducing the incidence of low output syndrome (i.e., the requirement for inotropic or balloo...
Eligibility Criteria
Inclusion
- Patient has been referred for isolated coronary bypass surgery.
- LV grade 3 or 4, LVEF \<40% by angio, echo, RNA.
Exclusion
- Patient is undergoing reoperative surgery (i.e., has had any previous cardiac surgery)
- Surgeon has planned another procedure in addition to coronary bypass surgery (e.g., valve repair, replacement, ascending aorta repair or replacement, left ventricular aneurysm resection, repair of congenital defect, carotid surgery, repair of abdominal aortic aneurysm).
- Patient is scheduled for minimally invasive surgery.
- More recent assessment of LV function with LV grade 1 0r 2, LVEF\>40%.
- 5 or 6 days post MI.
Key Trial Info
Start Date :
August 1 1999
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
800 Patients enrolled
Trial Details
Trial ID
NCT00188994
Start Date
August 1 1999
Last Update
December 29 2005
Active Locations (1)
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1
University Health Network
Toronto, Ontario, Canada, M5G 2C4