Status:
COMPLETED
Paclitaxel, Carboplatin, and Oral Etoposide Followed by Weekly Paclitaxel in High Grade Neuroendocrine Carcinoma
Lead Sponsor:
SCRI Development Innovations, LLC
Collaborating Sponsors:
Bristol-Myers Squibb
Conditions:
Neuroendocrine Carcinoma
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
carboplatin and etoposide, followed by maintenance therapy with weekly paclitaxel in patients with poorly differentiated neuroendocrine carcinomas. We hope to identify a "standard treatment" for this ...
Detailed Description
Upon determination of eligibility, patients will be receive: * Paclitaxel + Carboplatin + Etoposide
Eligibility Criteria
Inclusion
- To be included in this study, you must meet the following criteria:
- Metastatic poorly differentiated neuroendocrine carcinoma
- Unknown primary site
- Able to perform activities of daily living with minimal assistance
- Measurable or evaluable disease
- Adequate bone marrow, liver functions and kidney function
- No previous treatment with chemotherapy
- Understand the nature of this study and give written informed consent.
Exclusion
- You cannot participate in this study if any of the following apply to you:
- Age \< 18 years
- Previous malignancy within five years
- Women pregnant or lactating
- Recent history of cardiovascular disease
- Meningeal metastases
- Please note: There are additional inclusion/exclusion criteria. The study center will determine if you meet all of the criteria. If you do not qualify for the trial, study personnel will explain the reasons. If you do qualify, study personnel will explain the trial in detail and answer any questions you may have.
Key Trial Info
Start Date :
December 1 1998
Trial Type :
INTERVENTIONAL
End Date :
January 1 2007
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00193531
Start Date
December 1 1998
End Date
January 1 2007
Last Update
April 11 2023
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