Status:
COMPLETED
Pilot Study of Mycophenolate Mofetil in Congenital Uropathies
Lead Sponsor:
Northwell Health
Collaborating Sponsors:
Hoffmann-La Roche
University of Medicine and Dentistry of New Jersey
Conditions:
Congenital Urological Abnormalities
Eligibility:
All Genders
3-16 years
Phase:
PHASE1
Brief Summary
Congenital or hereditary structural anomalies of the genitourinary tract account for approximately half of all cases of end stage renal disease in the pediatric population. Despite optimal medical man...
Detailed Description
Sustained activation of the immune system may contribute to progressive renal injury in all forms of chronic kidney disease. There is extensive proliferation of renal tubular epithelial cells and fibr...
Eligibility Criteria
Inclusion
- Age 3-16 GFR \<50 ml/min/1.73 m2 Congenital abnormality of urinary tract
Exclusion
- Known hepatic, hematologic, GII, infectious disease Sensitivity to MMF Glomerular disease
Key Trial Info
Start Date :
March 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2007
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00193635
Start Date
March 1 2002
End Date
August 1 2007
Last Update
October 19 2007
Active Locations (3)
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1
Robert Wood Johnson Medical center
New Brunswick, New Jersey, United States, 08903-0019
2
Schneider Children's Hospital
New Hyde Park, New York, United States, 11040
3
Cornell Weill Medical Center
New York, New York, United States, 10021-4873