Status:
TERMINATED
Rt-PA Infusion Versus Catheter Exchange for Dialysis Catheter Malfunction Due to Fibrin Sheath
Lead Sponsor:
University of Pennsylvania
Collaborating Sponsors:
Genentech, Inc.
Conditions:
Dialysis Catheter Fibrin Sheath
Clotted Dialysis Catheter
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Treating central venous dialysis catheter malfunction due to fibrin sheath formation with rt-PA(TPA)infusion will give equal patency rates in a more cost effective manner when compared to catheter exc...
Detailed Description
Patients who come to the Hospital of the University of Pennsylvania, Presbyterian Medical Center or American Access in Northeast Philadelphia with a dialysis catheter that's not functioning well, will...
Eligibility Criteria
Inclusion
- Patients with tunneled hemodialysis catheters who have clinical evidence of catheter tip clot and fibrin sheath formation
Exclusion
- Malpositioned or kinked catheter requiring catheter change
- Complete thrombosis of the catheterized vein
- Evidence of catheter related infection
- GI bleed within 6 weeks
- Cerebral Infarct within 6 months
- Major surgery within 4 weeks
- Platelet count below 25000
- INR above 2.0
- Sepsis
- Pregnancy
- Inability to give consent
Key Trial Info
Start Date :
March 1 2003
Trial Type :
INTERVENTIONAL
End Date :
March 1 2005
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00194181
Start Date
March 1 2003
End Date
March 1 2005
Last Update
July 17 2006
Active Locations (1)
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1
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104