Status:
SUSPENDED
Effect of Cytokines on Growth of Children With Chronic Kidney Failure
Lead Sponsor:
Weill Medical College of Cornell University
Collaborating Sponsors:
Genentech, Inc.
Conditions:
Chronic Renal Insufficiency
Eligibility:
All Genders
6-21 years
Phase:
PHASE4
Brief Summary
Children with chronic kidney failure often do not grow well. This study examines the possible causes of growth failure in these children and the response to recombinant human growth hormone. The growt...
Detailed Description
Children with chronic renal failure (CRF; estimated creatinine clearance less than 75ml/min/1.73 m2) and end-stage renal disease (ESRD; dialysis dependent) have marked growth retardation and often do ...
Eligibility Criteria
Inclusion
- Current height \< 2SD (or \< 3rd percentile) for chronological age
- Chronic renal failure (estimated creatinine clearance \<75 mL/min/1.73m2) or ESRD (as defined by receiving maintenance HD or PD)
- Age \< 21 years and /or growth potential demonstrable by bone age
Exclusion
- Unable or unwilling to adhere to the protocol
- Additional diagnoses that could impair responsiveness to GH, e.g. dwarfism syndromes, significant extra-renal organ disease, e.g. chronic liver disease, or chronic corticosteroid therapy
Key Trial Info
Start Date :
April 1 1997
Trial Type :
INTERVENTIONAL
End Date :
May 1 2003
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00194883
Start Date
April 1 1997
End Date
May 1 2003
Last Update
November 21 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Weill Medical College of Cornell University
New York, New York, United States, 10021