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Status:

TERMINATED

Both Exercise and Adenosine Stress Testing

Lead Sponsor:

Midwest Heart Foundation

Collaborating Sponsors:

GE Healthcare

Astellas Pharma US, Inc.

Conditions:

Coronary Artery Disease

Eligibility:

FEMALE

60+ years

Phase:

PHASE4

Brief Summary

The purpose of this study is to compare the 2-year cardiac outcomes for women with limited exercise capability based on the resuls of either pharmacological stress myocardial perfusion imaging or a co...

Detailed Description

Coronary artery disease remains the leading cause of morbidity and mortality in women accounting for more than 250,000 deaths per year. Despite the high prevalence in ischemic heart disease in women, ...

Eligibility Criteria

Inclusion

  • Female
  • Age greater to or equal to 60 years old
  • Must present with chest pain, fatigue, or other anginal equivalent symptoms
  • Must be referred for stress testing based on clinical indications
  • Must be able to provide written informed consent

Exclusion

  • Women with known coronary artery disease (\>50% lesion OR prior MI OR prior revascularization)
  • Inability to perform any exercise on a treadmill
  • Nuclear medicine study within the preceding 30 days
  • Contraindication to adenosine, including moderate to severe COPD or asthma, second or third degree AV block, or known hypersensitivity to adenosine or aminophylline
  • Left bundle branch block or electronic ventricular pacemaker
  • Significant valvular heart disease
  • Hemodynamic instability (blood pressure \>210/110 ml/Hg or \<90/60 mm/Hg)
  • 2° or 3° atrioventricular block
  • Symptomatic heart failure
  • Ingestion of theophylline or dipyridamole within the preceding 48 hours
  • Unavailability for follow-up

Key Trial Info

Start Date :

June 1 2005

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

Estimated Enrollment :

200 Patients enrolled

Trial Details

Trial ID

NCT00200629

Start Date

June 1 2005

Last Update

August 9 2011

Active Locations (20)

Enter a location and click search to find clinical trials sorted by distance.

Page 1 of 5 (20 locations)

1

Southwest Heart

Tucson, Arizona, United States, 85715

2

Sutter Roseville Medical Center

Roseville, California, United States, 95661-3037

3

Sacramento Heart & Vascular Research Center

Sacramento, California, United States, 95825

4

Delaware SPECT Imaging

Newark, Delaware, United States, 19713