Status:
COMPLETED
Effects of Anticipation of Pain Relief on Brain Mechanisms
Lead Sponsor:
University of Michigan
Collaborating Sponsors:
National Center for Complementary and Integrative Health (NCCIH)
Conditions:
Pain
Eligibility:
All Genders
20-30 years
Phase:
NA
Brief Summary
This study will use brain imaging technology to examine chemical systems in the brain that suppress pain and stress when an individual has an expectation of pain relief.
Detailed Description
Evidence suggests that the expectation of pain relief, even if a person receives only a placebo, can provide actual therapeutic benefits. The µ-opioid receptor system, located in the brain, is activat...
Eligibility Criteria
Inclusion
- Willing and able to comply with all study requirements
Exclusion
- Presence of pain at study entry
- Personal or first-degree (e.g., mother, father, sister, brother) family history of neurologic or psychiatric disorders
- History of substance abuse or dependence
- Left-handed or ambidextrous
- Positive urine toxicology screen
- Acute or uncorrected medical illness that may interfere with the study
- Unable to tolerate brain scanning procedures
- Current treatment with antipsychotics, mood stabilizers, isoniazid (a drug for tuberculosis \[TB\]), glucocorticoids/mineralocorticoids, psychostimulant appetite suppressants, or centrally active antihypertensive drugs
- Treatment with hormones, antidepressants, or opioids within 6 months prior to study entry
- Treatment with sedative hypnotic medications or over-the-counter sleeping aids within 1 month prior to study entry
- Diagnosis of depression
- Competitive exercise, or exercise exceeding 1 hour each day
- Regular smoking within 5 years prior to study entry
Key Trial Info
Start Date :
September 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2008
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00200876
Start Date
September 1 2003
End Date
June 1 2008
Last Update
March 24 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Michigan Medical Center
Ann Arbor, Michigan, United States, 48109