Status:
COMPLETED
Asthma, a Disease Due to a Lack of Bacterial Infections in Childhood.
Lead Sponsor:
The Netherlands Asthma Foundation
Conditions:
Food Allergy
Atopic Dermatitis
Eligibility:
All Genders
Phase:
NA
Brief Summary
The degree of TH1-skewing by mycobacteria is controlles by NRAMP1 gene polymorphisms and related to the degree of inhibition of TH2-mediated disease.
Detailed Description
A randomised single blinded intervention study in high-risk newborns vaccinated at the age of 6 weeks with BCG or placebo. Inclusion: high-risk was defined as either a mother or a father and a siblin...
Eligibility Criteria
Inclusion
- high-risk was defined as either a mother or a father plus a sibling with present or past atopic disease.
Exclusion
- maternal infection in the last week of pregnancy, the use of immunomodulatory drugs or antibiotics during pregnancy (mother) or directly post partum (newborn)
Key Trial Info
Start Date :
January 1 1999
Trial Type :
INTERVENTIONAL
End Date :
July 1 2005
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00200928
Start Date
January 1 1999
End Date
July 1 2005
Last Update
April 4 2006
Active Locations (1)
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1
Wilhelmina Children's Hospital (UMCU)
Utrecht, Utrecht, Netherlands, 3508AB