Status:
COMPLETED
Effects of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease (COPD)
Lead Sponsor:
Queen's University
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
40-80 years
Phase:
PHASE4
Brief Summary
Human and animal studies have shown that inhaled corticosteroids (ICS) decrease airway blood flow . This effect is immediate (within 30 minutes), transient (lasting 90 minutes), and in animal studies ...
Detailed Description
This will be a single site, pilot, randomized, double-blinded, placebo-controlled, cross-over study that will be conducted at this centre. Subjects will be required to complete four (4) visits to the ...
Eligibility Criteria
Inclusion
- FEV1 less than/equal to 70 % predicted, FEV1/FVC ratio less than/equal to 70%, and FRC greater than/equal to 120 % predicted
- Moderate to severe chronic activity-related dyspnea (modified Baseline Dyspnea Index focal score less than/equal to 6)
- Clinically stable as defined by no changes in medication dosage or frequency of administration with no exacerbations or hospital admissions in the preceding four weeks
- Males or females greater than 40 years of age;
- A cigarette smoking history of at least 20 pack-years
- Able to perform all study procedures and sign informed consent
Exclusion
- History of asthma, atopy or nasal polyps
- Recent history of cardiovascular disease (\< 1 year) or other significant disease that could contribute to dyspnea or exercise limitation
- Oxygen saturation less than 80% during exercise on room air
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2005
Estimated Enrollment :
4 Patients enrolled
Trial Details
Trial ID
NCT00202189
Start Date
September 1 2005
End Date
November 1 2005
Last Update
August 13 2008
Active Locations (1)
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1
Respiratory Investigation Unit
Kingston, Ontario, Canada, K7L 2V7