Status:
UNKNOWN
Normal Binding of R-[11C]PK11195 in Human Subjects
Lead Sponsor:
Amsterdam UMC, location VUmc
Conditions:
Normal Aging
Eligibility:
All Genders
18-80 years
Phase:
PHASE1
Brief Summary
This is a study using Positron Emission Tomography (PET) to study the normal distribution of the PET ligand (R)-\[11C\]PK11195. This ligand will be used to study inflammation in the brain in several b...
Detailed Description
At the University Hospital Vrije Universiteit the PET ligand PK11195 labeled with carbon-11, (R)-\[11C\]PK11195, will be used to study microglia activation in-vivo in patients with traumatic brain dam...
Eligibility Criteria
Inclusion
- Male and female subjects
- Good physical and mental Health which will be evaluated with medical history, a physical examination and screening laboratory tests (see appendix 1).
- Age between 18 and 40 years (20 subjects) and between 40 and 80 years (20 subjects).
- Mini Mental State score \>27
- Body Mass Index (B.M.I.) between 20 -25.
- Written informed consent of the subject.
- Hb must be \>8 mmol \\ liter at the time of the screening.
Exclusion
- Previous neurotrauma with loss of consciousness
- Any clinical significant abnormality of any clinical laboratory test, including drug screening, or ECG abnormality.
- History of hypertension
- Any subject who has received any investigational medication within 30 days prior to the start of this study, or who is scheduled to receive an investigational drug.
- History of psychiatric or neurological illness
- History of psychiatric or neurological illness in first-degree relatives
- History of alcohol and/or drug abuse (DSM-IV criteria)
- Current use of any medication
- Blood donation within 3 months before the scan day
- Claustrophobia
- Metal objects in or around the body (braces, pacemaker, metal fragments);
Key Trial Info
Start Date :
February 1 2001
Trial Type :
INTERVENTIONAL
End Date :
January 1 2007
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00205595
Start Date
February 1 2001
End Date
January 1 2007
Last Update
July 8 2008
Active Locations (1)
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1
VU University Medical Centre
Amsterdam, Netherlands, 1081 HV