Status:
SUSPENDED
Positron Emission Tomography of Amyloid in Alzheimer's Disease
Lead Sponsor:
Amsterdam UMC, location VUmc
Conditions:
Alzheimer's Disease
Eligibility:
MALE
60-80 years
Phase:
PHASE1
Brief Summary
In this study in-vivo quantification of amyloid load will be performed in patients with AD, MCI and normal controls with Positron Emission Tomography. For this the PET tracers \[11C\]PIB and \[18F\]FD...
Detailed Description
Alzheimer's disease (AD) is a fatal neurodegenerative disorder characterized by progressive impairment in daily life, cognitive deterioration, and a variety of neuropsychiatric and behavioural symptom...
Eligibility Criteria
Inclusion
- Clinical diagnosis of probable Alzheimer's disease (NINCDS-ADRDA criteria)
- Clinical diagnosis of MCI according to the criteria of Petersen
- Age between 60 and 80 years
- Written informed consent of each subject.
- Hb must be \>8 mmol \\ litre at the time of the screening for males and \>7 mmol\\litre for females.
- Weight \>50 kg
- All subjects have to be "wilsbekwaam"
Exclusion
- Any clinical significant abnormality of any clinical laboratory test
- Any subject who has received any investigational medication within 30 days prior to the start of this study, or who is scheduled to receive an investigational drug.
- Major psychiatric or neurological disorder other than AD
- History of AD in first degree relatives (controls only)
- History of alcohol and/or drug abuse (DSM-IV criteria)
- Any sign of cardiovascular disease including ECG
- Claustrophobia
- Mini Mental State Score below 20
- Use of non-steroid anti-inflammatory drugs
- Abnormalities on MRI other than white matter changes or an incidental small lacunar lesion.
- Blood donation within 3 months before the scan day
- Metal objects in or around the body (braces, pacemaker, metal fragments)
- Use of antithrombotics and ASA
- Fall ≤ 6 months or any relevant gait disorder
- Need for elective surgery ≤ 3 months
Key Trial Info
Start Date :
October 1 2005
Trial Type :
INTERVENTIONAL
End Date :
December 1 2009
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00205621
Start Date
October 1 2005
End Date
December 1 2009
Last Update
September 8 2006
Active Locations (1)
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1
VU University Medical Center
Amsterdam, Netherlands, 1081 HV