Status:

COMPLETED

Changes in Adiposity, Metabolic Measures From Atypicals to Aripiprazole

Lead Sponsor:

Washington University School of Medicine

Collaborating Sponsors:

Bristol-Myers Squibb

Conditions:

Schizophrenia

Type 2 Diabetes Mellitus

Eligibility:

All Genders

18-60 years

Phase:

PHASE4

Brief Summary

This proposal aims to use well-validated methodologies such as dual energy x-ray absorptiometry (DEXA), frequently sampled oral glucose tolerance tests (fsOGTTs), and hyperinsulinemic euglycemic clamp...

Detailed Description

Schizophrenia is associated with increased rates of obesity, hyperglycemia, dyslipidemia and type 2 diabetes mellitus (T2DM), causing increased morbidity and mortality due to acute (e.g., diabetic ket...

Eligibility Criteria

Inclusion

  • Patient meets DSM-IV criteria for Schizophrenia
  • 18-60 years of age or older
  • Able to give informed consent
  • Treated with olanzapine, quetiapine, risperidone or ziprasidone for greater than or equal to 3 months prior to enrollment

Exclusion

  • pregnant or breastfeeding women will be excluded
  • Meets DSM-IV criteria for substance abuse or dependence within past 6 months
  • involuntary legal status (as per Missouri law)
  • any serious medical disorder that may confound assessment of symptoms
  • subjects taking prescription medications except psychotropic meds
  • meets DSM-IV criteria for Mental Retardation (mild or worse)
  • Subjects taking tricyclic antidepressants or mood stabilizers

Key Trial Info

Start Date :

February 1 2005

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

August 1 2009

Estimated Enrollment :

51 Patients enrolled

Trial Details

Trial ID

NCT00205660

Start Date

February 1 2005

End Date

August 1 2009

Last Update

January 15 2019

Active Locations (1)

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1

Washington University School of Medicine

St Louis, Missouri, United States, 63110