Status:
TERMINATED
A Trial of Inflammatory Markers, Depressive Symptoms, and Heart Disease
Lead Sponsor:
New York State Psychiatric Institute
Collaborating Sponsors:
National Alliance for Research on Schizophrenia and Depression
Conditions:
Depression
Coronary Artery Disease (CAD)
Eligibility:
All Genders
18-60 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to examine the relationship between depressive symptoms and markers of inflammation, two predictors of heart disease.
Detailed Description
Depressive symptoms and inflammatory markers have both been proposed as measures that indicate/precede coronary artery disease (CAD). However, no controlled research study has tested the impact of the...
Eligibility Criteria
Inclusion
- Age 18 - 60
- Mild depression
- Inflammatory markers: CRP \> 2
Exclusion
- Non-English or Non-Spanish speakers
- Active suicidal or homicidal ideation
- Current alcohol or other substance abuse
- Psychotic features
- Current personality disorder
- History of bipolar depressive disorder
- Any current psychotic disorder
- Current major depressive disorder
- Current depression treatment or treatment within preceding 6 weeks
- History of chronic liver and/or renal disease
- Current use or contraindication to any of the tested medications
- Absence of a response to a previous adequate trial of any of the tested medications
- Pregnant or lactating women
- History of coronary artery disease
- Current use of statins
- Current, regular aspirin use
- Antibiotic use within the previous four weeks
- History of diabetes
- Inflammatory diseases
- Meets NCEP guidelines for cholesterol lowering therapy
Key Trial Info
Start Date :
April 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2009
Estimated Enrollment :
7 Patients enrolled
Trial Details
Trial ID
NCT00208117
Start Date
April 1 2005
End Date
January 1 2009
Last Update
May 31 2012
Active Locations (1)
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1
Columbia University Department of General Medicine
New York, New York, United States, 10032