Status:
TERMINATED
Hepatitis C Treatment of Inmates
Lead Sponsor:
Haukeland University Hospital
Collaborating Sponsors:
Bergen Prison, Norwegian Correctional Service
Hoffmann-La Roche
Conditions:
Chronic Hepatitis C
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Hepatitis C infection is a prevalent chronic disease. It is particularly prevalent among intravenous drug abusers. Bergen fengsel is a regional prison housing 250 inmates, of which as many as 70 are r...
Eligibility Criteria
Inclusion
- Serologic evidence of chronic hepatitis C infection by an anti-HCV test
- Serum HCV-RNA quantifiable at \> 600 IU/mL or 1000 copies/mL by the Roche AMPLICOR HCV MONITOR Test, v2.0
- Patients with both normal or elevated serum ALT are eligible
- Compensated liver disease (Child-Pugh grade A clinical classification)
- Patients with cirrhosis or transition to cirrhosis must have an abdominal ultrasonography, CT scan or MRI scan without evidence of hepatocellular carcinoma and a serum AFP \< 100 ng/mL within 2 months of randomization
- Negative urine or blood pregnancy test (for women of childbearing potential) documented within the 24 hour period prior to first dose of study drug
- All fertile males and females receiving RBV must be using two forms of effective contraception during treatment and during the 6 months after treatment ends
Exclusion
- Women with ongoing pregnancy or breat feeding
- Therapy with any systemic anti-viral, anti-neoplastic or immunomodulatory treatment (including supraphysiologic soses of steroids and radiation) \< 6 months prior to the first dose of study drug
- Any investigational drug \< 6 weeks prior to the first dose of study drug Positive test at screening for anti-HAV IgM Ab, HBsAg, anti-HBsAg, anti-HBc Ab, anti-HIV Ab.
- History or evidence of a medical condition associated with chronic liver disease other than HCV (e.g. hemochromatosis, autoimmune hepatitis, metabolic liver disease, alcoholic liver disease, toxin exposures)
- History or evidence of bleeding from esophageal varices or other conditions consistent with decompensated liver disease
- Neutrophil count \< 1500/mm or platelet count \< 90,000 cells/mm at screening
- Serum creatinine level \> 1,5 times the ULN at screening
- History of severe psychiatric disease, especially depression. Severe psychiatric disease is defined as treatment with an antidepressant medication or neuroleptica at therapeutic doses for major depression or psychosis, respectively for at least 3 months at any previous time, or any history of the following; a suicidal attempt, hospitalization for psychiatric disease or a period of disability due to psychiatric disease
- History of severe seizure disorder or current anticonvulsant disease
- History of immunologically mediated disease (e.g. IBD, ITP, LED, AIHA, scleroderma, severe psoriasis or RA etc.)
- History or other evidence of chronic pulmonary disease associated with functional limitation
- History of major organ transplantation with an existing functional graft
- History of severe cardiac disease (e.g. NYHA Functional Class III or IV, myocardial infarction within 6 months of ventricular arrhythmias requiring ongoing treatment, unstable angina or other significant CVD)
- History or other evidence of severe illness, malignancy or other conditions which would make the patient, in the opinion of the investigator, unsuitable for the study
- Evidence of severe retinopathy (e.g. CMV retinitis, macula degeneration)
- Evidence of ongoing drug abuse (including excessive alcohol consumption)
- Inability or unwillingness to provide informed consent or abide by the requirements of the study
- Male partners of women who are pregnant
- Hemoglobin \< 12 g/dL in women or \< 13g/dL in men at screening
- Any patient with an increased baseline risk for anemia or for whom anemia would be medically problematic
- Patients with documented or presumed coronary artery disease or cerebrovascular disease should not be enrolled if, in the judgement of the investigator, an acuter decrease in hemoglobin by up to 4 g/dL would not be well-tolerated
Key Trial Info
Start Date :
August 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2009
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT00209898
Start Date
August 1 2003
End Date
January 1 2009
Last Update
March 20 2015
Active Locations (1)
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1
Unit for infectious diseases outpatient clincic, Dept. Internal Medicine
Bergen, Bergen, Norway, N-5021