Status:
COMPLETED
Non Invasive Ventilation and Weaning : VENISE Trial
Lead Sponsor:
University Hospital, Rouen
Conditions:
Weaning
Chronic Respiratory Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The clinical efficacy of noninvasive ventilation (NIV) has now been demonstrated in the management of acute-on-chronic respiratory failure (ACRF) of various etiologies. Endotracheal mechanical ventila...
Eligibility Criteria
Inclusion
- endotracheal mechanical ventilation for 48 hours or more for acute respiratory failure in chronic respiratory failure patients (obstructive or restrictive disease),
- patient ready to be weaned (steady respiratory and hemodynamic conditions for 24 hours),
- spontaneous breathing trial failure occurring between 5 minutes and 2 hours, judged on clinical and/or arterial blood gas tolerance,
- written informed consent obtained (patient or family)
Exclusion
- respiratory and hemodynamic instability
- initial intubation considered as difficult
- swallowing disorders suspected
- inefficient cough
- bronchial hypersecretion at the weaning time
- non cooperant patient
- contra-indications for nasal or facial mask (facial skin lesions,...)
- recent history of upper gastro-intestinal surgery
- recent history of myocardial infarction
Key Trial Info
Start Date :
January 1 2002
Trial Type :
INTERVENTIONAL
End Date :
September 1 2008
Estimated Enrollment :
205 Patients enrolled
Trial Details
Trial ID
NCT00213499
Start Date
January 1 2002
End Date
September 1 2008
Last Update
February 16 2012
Active Locations (1)
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1
Rouen University Charles Nicolle Hospital
Rouen, France, 76031