Vascular Pathophysiology in Obstructive Sleep Apnea

Status:

WITHDRAWN

Vascular Pathophysiology in Obstructive Sleep Apnea

Lead Sponsor:

University of Wisconsin, Madison

Conditions:

Obstructive Sleep Apnea

Eligibility:

All Genders

18+ years

Phase:

Brief Summary

Obstructive sleep apnea (OSA) is a medical problem whose importance is increasing in recognition and awareness. The National Commission on Sleep Disorders estimates that 15 million Americans have OSA,...

Eligibility Criteria

Inclusion

Patients with Sleep Disordered Breathing:
Significant obstructive sleep apnea as verified by complete overnight polysomnography with apnea-hypopnea index (AHI) \> 10 events per hour.
Fasting total cholesterol \< 240 mg/dL
Fasting blood glucose \< 120 mg/dL
Control subjects:
Free of sleep disordered breathing verified by complete overnight polysomnography or oxygen desaturation screening (AHI \< 5 events per hour)
Fasting total cholesterol \< 240 mg/dL
Fasting blood glucose \< 120 mg/dL

Exclusion

Presence of any cardiovascular diseases or medical conditions that will affect vascular responses (other than sleep apnea)
Subject taking any vasoactive medications, willing to stop taking vitamins or supplements for study participation
Current smokers
History of adverse reaction to allopurinol, acetylcholine, nitroprusside, verapamil or lidocaine

Key Trial Info

Start Date :

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

Estimated Enrollment :

Patients enrolled

Trial Details

Trial ID

NCT00214084

Last Update

October 8 2015

Active Locations (1)

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