Status:
COMPLETED
Effects of Duloxetine vs. Escitalopram on Heart Rate Variability in Depression
Lead Sponsor:
Duke University
Collaborating Sponsors:
Forest Laboratories
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
20-60 years
Phase:
PHASE2
PHASE3
Brief Summary
Low heart rate variability is a marker of increased risk of cardiac mortality, and is observed in depressed coronary artery disease patients. Some antidepressants may themselves, however, decrease hea...
Detailed Description
Evaluation of heart rate variability (HRV) has been shown to be a valuable tool for measuring autonomic dysfunction associated with depression and with cardiac disease. Low HRV is a marker of increase...
Eligibility Criteria
Inclusion
- adults 20-60 years of age
- a primary diagnosis of depression using DSM-IV criteria
- written informed consent
- a negative serum pregnancy test for women of childbearing potential
Exclusion
- history of cardiovascular disease
- history of hypertension
- history of bipolar disorder
- history of schizophrenia or other psychotic disorder
- alcohol or other substance abuse within the last 3 months
- history of cognitive impairment
Key Trial Info
Start Date :
July 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2007
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT00215228
Start Date
July 1 2005
End Date
August 1 2007
Last Update
July 21 2014
Active Locations (1)
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1
Duke University Medical Center
Durham, North Carolina, United States, 27705