Status:
COMPLETED
The Study of the Safety and Efficacy of Ampligen in Chronic Fatigue Syndrome
Lead Sponsor:
AIM ImmunoTech Inc.
Conditions:
Chronic Fatigue Syndrome
Myalgic Encephalomyelitis
Eligibility:
All Genders
18-60 years
Phase:
PHASE3
Brief Summary
multi-center, double-blind, randomized, placebo-controlled study of the safety and efficacy.
Detailed Description
This study will be a prospective, double-blind, randomized, placebo-controlled, equal parallel groups study conducted at up to fifteen (15) centers to compare the safety and efficacy of Ampligen® IV v...
Eligibility Criteria
Inclusion
- A diagnosis of CFS, as defined by the Center for Disease Control (1988 CDC case definition) \> 12 months (Appendix D).
- Age Range: \> 18 years old, \< 60 years old.
- Males or non-pregnant, non-lactating females: Females must be of non-child bearing potential (either post-menopausal for two (2) years or surgically sterile including tubal ligation) or using an effective means of contraception (birth control pills, intrauterine device, diaphragm). Females who are less than two (2) years post-menopausal, those with tubal ligations and those using contraception must have a negative serum pregnancy test within the two (2) weeks prior to the first study medication infusion. Females of child bearing potential agree to use an effective means of contraception from four (4) weeks prior to the baseline pregnancy test until four (4) weeks after the last study medication infusion.
- A reduced quality of life as determined by a documented KPS of 40 to 60 on three (3) occasions, each at least 14 days apart, during the twelve (12) weeks immediately preceding the start of study drug infusions. The KPS must be rounded in increments of ten (10).
- Ability to walk (minimum of 20 seconds) on the moving treadmill (grade = 0%; belt speed = 1 mph) on a minimum of two (2) occasions during the twelve (12) weeks immediately preceding study entry.
- Laboratory documentation (baseline or historical following onset of CFS/ME) of a negative ANA or a negative anti-ds (double-stranded) DNA, a negative Rheumatoid Factor, and an erythrocyte sedimentation rate (ESR).
- Laboratory documentation that the patient is euthyroid (patients on thyroid replacement therapy must be on a stable dose during the eight (8) week washout period) based on a thyroid profile (T4, T3, TSH, T3 uptake and Free T4 index) performed during baseline.
- Ability to provide written informed consent indicating awareness of the investigational nature of this study.
Exclusion
- \-
Key Trial Info
Start Date :
December 1 1998
Trial Type :
INTERVENTIONAL
End Date :
February 1 2004
Estimated Enrollment :
234 Patients enrolled
Trial Details
Trial ID
NCT00215800
Start Date
December 1 1998
End Date
February 1 2004
Last Update
April 17 2013
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.