Status:
COMPLETED
Effects of Pre-Session Supplemental Hydromorphone on Drug Seeking Behavior in Opioid Dependent Individuals
Lead Sponsor:
National Institute on Drug Abuse (NIDA)
Collaborating Sponsors:
Wayne State University
Conditions:
Heroin Dependence
Opioid-Related Disorders
Eligibility:
All Genders
18-55 years
Brief Summary
The purpose of this study is to determine whether the opportunity to take free supplemental hydromorphone (HYD) influences drug seeking behavior in heroin dependent individuals.
Detailed Description
Drug dependence is a condition in which drug seeking holds a higher priority than behaviors controlled by other reinforcers. Learning to understand, predict, and control this maladaptive choice behavi...
Eligibility Criteria
Inclusion
- Current opiate dependence, verified by the structured clinical interview for DSM-IV (SCID) and Addiction Severity Index (ASI)
- Positive urine test for opiates
- Agreement to use adequate contraception for the duration of the study
- Able to read and write English
Exclusion
- DSM-IV diagnosis of a psychiatric illness
- History of or current neurological disease, including structural brain abnormalities, seizures, infection, peripheral neuropathy, and head trauma
- History of cardiovascular disease, myocardial infarction, chest pain, edema, systolic blood pressure greater than 160 mm Hg or less than 95 mm Hg, or diastolic blood pressure greater than 95 mm Hg
- Pulmonary disease, including obstructive pulmonary disease, cor pulmonale, tuberculosis, and asthma
- Systemic diseases, such as endocrinopathies, liver or kidney failure, myxedema, hypothyroidism, Addison's disease, or autoimmune disease
- Current alcohol or sedative drug dependence
- Pregnant or breastfeeding
- Currently receiving treatment for opioid dependence
- Known phobia of injections
Key Trial Info
Start Date :
September 1 2003
Trial Type :
OBSERVATIONAL
End Date :
July 1 2005
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT00218309
Start Date
September 1 2003
End Date
July 1 2005
Last Update
January 12 2017
Active Locations (1)
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1
Wayne State University
Detroit, Michigan, United States, 48207