Status:
COMPLETED
Dextromethorphan, Gabapentin, and Oxycodone to Treat Opioid-Induced Hyperalgesia
Lead Sponsor:
National Institute on Drug Abuse (NIDA)
Conditions:
Hyperalgesia
Opioid-Related Disorders
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
Individuals who reduce or stop use of opioid medications are at risk for developing hyperalgesia, which is an increased sensitivity to pain. This study will compare the effectiveness of dextromethorph...
Detailed Description
Opioid medications are frequently used for the treatment of moderate to severe pain; however, individuals who use opioids have a high risk of becoming addicted. Opioid users who abruptly stop using op...
Eligibility Criteria
Inclusion
- Be between the ages of 18 and 55 years of age.
- Meets DSM-IV diagnostic criteria for opioid dependence
- Taking a stable dose of methadone for 6 weeks prior to study entry and is compliant in methadone maintenance treatment
- Is in good physical health or under a physician's care if a medical condition requires ongoing treatment
Exclusion
- Known sensitivity to dextromethorphan, gabapentin, or oxycodone
- Currently dependent on alcohol, benzodiazepine, or any drug (other than nicotine)
- Currently in an acutely psychotic, severely depressed state and in need of inpatient treatment
- Immediate suicide risk
- Neurological or psychiatric illness (e.g., peripheral neuropathy, schizophrenia, neuropathic pain, Raynaud's disease, or urticaria)
- Acute medical condition that would make study participation medically dangerous (e.g., acute hepatitis, unstable cardiovascular disease, liver disease, or kidney disease)
- Liver enzyme values five times greater than normal
- Currently taking analgesic medication for a painful condition on a regular basis
- Current or past history of high blood pressure, heart disease, or stroke
- Currently using a pacemaker
- Pregnant or breastfeeding
Key Trial Info
Start Date :
October 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2007
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00218374
Start Date
October 1 2006
End Date
June 1 2007
Last Update
January 12 2017
Active Locations (1)
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1
University of California, Los Angeles
Los Angeles, California, United States, 90024