Status:
COMPLETED
Effect of Paroxetine on Smokers' Cardiovascular Response to Stress - 1
Lead Sponsor:
University of Minnesota
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Tobacco Use Disorder
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Smokers report that they often smoke cigarettes during stressful times. The combined effect of smoking and exposure to stress leads to exaggerated increases in blood pressure, heart rate and other mea...
Detailed Description
Smokers report that they often smoke cigarettes during stressful times. Smoking and stress produce similar physiological responses such as increases in heart rate, blood pressure, and adrenaline level...
Eligibility Criteria
Inclusion
- Smokes an average of at least 10 cigarettes per day during the year prior to enrollment
Exclusion
- Interested in quitting smoking within the 3 months following enrollment
- Current unstable medical condition
- Substance abuse within the year prior to enrollment
- Current use of any medications (e.g., psychoactive medications, antihypertensives) that, in the opinion of the investigators, might interfere with study measures or that would be expected to interact with paroxetine (e.g., CYP2D6 substrates)
- Smoking cessation therapy within the 3 months prior to enrollment
- Regular use of any form of tobacco other than cigarettes
- Significant psychiatric disorders as assessed by the PRIME-MD and verified by a clinician
- History of hypersensitivity to any selective serotonin reuptake inhibitor
- Pregnancy or breastfeeding
Key Trial Info
Start Date :
October 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2010
Estimated Enrollment :
105 Patients enrolled
Trial Details
Trial ID
NCT00218439
Start Date
October 1 2005
End Date
August 1 2010
Last Update
November 1 2019
Active Locations (1)
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1
College of Pharmacy
Minneapolis, Minnesota, United States, 55455