Status:
COMPLETED
Cognitive Effects of Aerobic Exercise for MCI Adults
Lead Sponsor:
Seattle Institute for Biomedical and Clinical Research
Collaborating Sponsors:
Alzheimer's Association
Conditions:
Mild Cognitive Impairment
Eligibility:
All Genders
55-90 years
Phase:
PHASE2
Brief Summary
The specific aims for the study will be to determine if aerobic exercise enhances cognition for older adults who are at greater risk for developing Alzheimer's disease, and to evaluate whether change ...
Detailed Description
The specific aims for the study are 1) to determine if aerobic exercise enhances cognition for older adults with mild cognitive impairment, 2) to evaluate whether change in insulin sensitivity predict...
Eligibility Criteria
Inclusion
- diagnosed with mild cognitive impairment, at least 55 years of age, sedentary (elevated HR \& SOB \<3x/wk and \<30min on each occasion), overall good general health, willing to exercise at least 4 times/wk for 6 months
Exclusion
- Significant neurologic disease that might affect cognition, such as a diagnosis of Alzheimer's disease, stroke, Parkinson's disease, multiple sclerosis, or severe head injury with loss of consciousness; significant medical illness or organ failure such as liver disease, significant elevations in liver function tests, kidney disease, uncontrolled hypertension (BP\>140/90 on medication); cardiovascular disease defined as any acute cardiovascular abnormality, such as new or unstable angina, uncontrolled irregular heart beat (treated a-fib and occasional PVC's are OK) or symptomatic heart failure, acute shortness of breath for any reason, or clinically significant edema; chronic lung disease, or musculoskeletal impairment (impaired walking); current use of anti-psychotic, anti-convulsant, anti-coagulant, sedative, or any cognition-enhancing medications; current or previous use of hypoglycemic agents or insulin.
Key Trial Info
Start Date :
January 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2008
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00220467
Start Date
January 1 2005
End Date
May 1 2008
Last Update
July 30 2008
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Veterans Affairs Puget Sound Health Care System
Seattle, Washington, United States, 98108
2
Veterans Affairs Puget Sound Health Care System
Tacoma, Washington, United States, 98493