Status:
TERMINATED
Folate and Protection Against Cervical Cancer
Lead Sponsor:
Sheffield Teaching Hospitals NHS Foundation Trust
Collaborating Sponsors:
World Cancer Research Fund International
Conditions:
Cervical Cancer
Eligibility:
FEMALE
Phase:
PHASE1
PHASE2
Brief Summary
This is a randomised double-blind placebo-controlled trial to see whether giving a low dose of the vitamins folic acid and riboflavin is beneficial to women who have very low grade abnormalities of th...
Detailed Description
The overall aim of the study is to evaluate interactions between intakes of folic acid and riboflavin with a common polymorphism relevant to folate metabolism, in determining the risk of cervical canc...
Eligibility Criteria
Inclusion
- biopsy-diagnosed CIN1 infection with oncogenic HPV
Exclusion
- Any other stage of cervical abnormality pregnant or planning a pregnancy diabetic taking B vitamin supplements taking anti-epileptic treatment taking methotrexate bleeding after intercourse abnormal GI function infection with chlamydia, HIV or other agent
Key Trial Info
Start Date :
July 1 2005
Trial Type :
INTERVENTIONAL
End Date :
May 1 2007
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT00220532
Start Date
July 1 2005
End Date
May 1 2007
Last Update
September 13 2006
Active Locations (1)
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1
University of Sheffield
Sheffield, South Yorkshire, United Kingdom, S10 2TN