Status:
COMPLETED
Mitochondrial Impairment in Muscle Insulin Resistance
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Diabetes
Obesity
Eligibility:
All Genders
30-55 years
Phase:
NA
Brief Summary
This investigation is being carried out to learn more about research findings from a study that was completed last year. Those findings revealed that within the skeletal muscle cells of individuals wi...
Detailed Description
Recent research from our laboratory has detected novel findings concerning damage to mitochondria within skeletal muscle in type 2 diabetes (type 2 DM), damage that is evident morphologically and by f...
Eligibility Criteria
Inclusion
- AGE 30 to 55 years old BMI 28 to 38 kg/m2 BLOOD PRESSURE Systolic \< 150 ; Diastolic \< 95 SEDENTARY Currently not engaged in a regular exercise program and a VO2 max pre-training value \< 55 ml/kg-fat free mass-min HEALTH (Group 1) Type 2 diabetes mellitus for \< 10 years and independent in SBGM HEALTH (Group 2) Non-diabetic with impaired glucose tolerance (as per ADA) or with Metabolic Syndrome (as per NCEP-ATP III)
- HEALTH Must be in good general health with no known h/o the following:
- liver disease, kidney disease, PVD (including diminished pulses, or H/O thrombophlebitis), heart disease (including any h/o MI), neuromuscular disease, neurological disease (including peripheral neuropathy or muscle wasting), paresis, edema , current malignancy, or any drug or alcohol abuse, LAB VALUES Enroll if: No Proteinuria (defined as \< 1+ protein on routine dipstick) Hct \> 34% ALT \< 80, AST \< 80, Alk Phos \< 240 sTSH \< 8 (Group 2) 2 hr glucose on OGTT \>140mg/dl but \< 200mg/dl or NCEP-ATP III criteria) Triglyceride \< 450 Cholesterol \< 300 Negative Urine Pregnancy
Exclusion
- (Group 1) anti-hypertensives, "statin" hypolipemics, and diabetic medications okay but exclude if taking: insulin, or a hypolipemic that is not a "statin" (Group 2) "statin" hypolipemic medications are okay. A hypolipemic that is not a "statin" will exclude.
- Inability and / or unwillingness to comply with the protocol as written Previous difficulty with lidocaine or other local anesthetic Claustrophobia Wt gain or loss of \> 3 kg during past 4 weeks
Key Trial Info
Start Date :
December 1 2003
Trial Type :
INTERVENTIONAL
End Date :
December 1 2006
Estimated Enrollment :
49 Patients enrolled
Trial Details
Trial ID
NCT00222924
Start Date
December 1 2003
End Date
December 1 2006
Last Update
December 19 2007
Active Locations (1)
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1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213