Status:
COMPLETED
In Vitro Studies on Pharmacological Regulation and Genetic Risk Factors of Peripheral Human Nociceptors
Lead Sponsor:
The University of Texas Health Science Center at San Antonio
Collaborating Sponsors:
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Pain
Eligibility:
All Genders
16-90 years
Brief Summary
This protocol is for a number of in vitro studies using human surgical biopsies and evaluating the pharmacology and genetics of human nociceptors ("pain detecting") neurons
Detailed Description
Purpose/Objectives a. Specific Aims Specific Aim 1: Characterize in humans the effects of inflammation and neuronal degeneration on peripheral levels of NPY, and related Y receptors (Y1, Y2, Y5) in p...
Eligibility Criteria
Inclusion
- Willingness to participate; identified indication to have a tooth extraction; 16-90 years old; diagnosis of normal pulp; or diagnosis of irreversible pulpitis requiring a symptom of spontaneous pain and positive and lingering response to pulp vitality test.
Exclusion
- History of taking steroids within the last month; history of taking analgesics in the last four hours.
Key Trial Info
Start Date :
October 1 2001
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 19 2019
Estimated Enrollment :
2007 Patients enrolled
Trial Details
Trial ID
NCT00223366
Start Date
October 1 2001
End Date
May 19 2019
Last Update
November 3 2020
Active Locations (1)
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1
The University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229