Status:
COMPLETED
CHROENDOHNPCC: Early Detection of Pre-cancer Lesions in Adults With Hereditary Nonpolyposis Colorectal Cancer Syndrome
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Colorectal Neoplasms, Hereditary Nonpolyposis
Eligibility:
All Genders
25-75 years
Phase:
PHASE2
Brief Summary
The aim of the study is to test the hypothesis that a chromoscopy colonoscopy is able to increase by 50 % the number of pre-cancer lesions or early cancer detected in patients with HNPCC syndrome, com...
Detailed Description
Patient with HNPCC syndrome confirmed by a mutation (MLH1, MSH2, MHS1) are involved in the study. Patient have 2 colonoscopy back to back. The second coloscopy is associated to chromoscopy with carmin...
Eligibility Criteria
Inclusion
- Patients with MLH1, MSH2 or MSH6 mutation.
- Patients concerned by early detection colonoscopy.
Exclusion
- Coloscopy of tracking since less 1an
- occlusive Syndrome contra-indicating the preparation for a total coloscopies
- Colectomies
- medical Conditions or serious illnesses contra-indicating a coloscopy of screening
- pregnant Woman or nursing
- Anomaly of coagulation contra-indicating the realization of biopsies and/or the exeresis of the lesion colorectal
Key Trial Info
Start Date :
July 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2008
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00224601
Start Date
July 1 2005
End Date
January 1 2008
Last Update
February 18 2011
Active Locations (1)
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1
Hopital Europeen Georges Pompidou
Paris, Île-de-France Region, France, 75015