Status:
COMPLETED
Transesophageal Echocardiography to Identify pAtients With Low Risk of Stroke in Atrial Fibrillation - TIARA Pilot Study
Lead Sponsor:
The Interuniversity Cardiology Institute of the Netherlands
Conditions:
Atrial Fibrillation
Stroke
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In this multi centre pilot study we will perform TEE in patients with AF who are eligible for VKA treatment. TTE will be used as pre-screening: if TTE shows left atrial abnormalities or aortic plaque,...
Detailed Description
BACKGROUND Atrial fibrillation (AF) is an independent risk factor for stroke. Therapy with vitamin K antagonists (VKA) and aspirin reduces the risk of thromboembolism (TE) dramatically. Risk stratific...
Eligibility Criteria
Inclusion
- Documented atrial fibrillation or atrial flutter, paroxysmal or permanent
- Conventional indication for VKA treatment
- Signed informed consent
Exclusion
- Planned electro cardioversion
- Very high risk of TE (previous ischemic stroke or systemic TE, symptoms of heart failure or left ventricular dysfunction, mitral valve stenosis, hypertrophic cardiomyopathy)
- Indication for VKA treatment other than atrial fibrillation (e.g. mechanic valve prosthesis)
- Atrial fibrillation secondary to reversible diseases (e.g. thyrotoxicosis)
- Contraindication for treatment with VKA, aspirin, or clopidogrel
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2009
Estimated Enrollment :
227 Patients enrolled
Trial Details
Trial ID
NCT00224757
Start Date
September 1 2005
End Date
September 1 2009
Last Update
September 7 2011
Active Locations (10)
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1
Jeroen Bosch Ziekenhuis
's-Hertogenbosch, Netherlands
2
Twenteborg
Almelo, Netherlands
3
VUMC
Amsterdam, Netherlands
4
Rijnstate Ziekenhuis
Arnhem, Netherlands