Status:
COMPLETED
Integrated Treatment for Cocaine and Mood Disorders - 1
Lead Sponsor:
National Institute on Drug Abuse (NIDA)
Conditions:
Cocaine Dependence
Depressive Disorder, Major
Eligibility:
All Genders
18-55 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to test whether cognitive behavioral therapy and bupropion hydrochloride will help cocaine users, who are depressed, reduce or end their cocaine use and improve their mood...
Detailed Description
The global aim of this study is to evaluate an "integrated" treatment approach for cocaine dependent patients with comorbid unipolar depression. It is hypothesized that a cognitive-behavioral psychoth...
Eligibility Criteria
Inclusion
- Generally physically healthy
- Aged 18-55
- Meets cocaine dependence by DSM-IV criteria
- Meets major depressive disorder or substance-induced depression disorder by DSM-IV criteria.
- Willing and able to participate in the 12 week treatment study and one year follow up.
Exclusion
- Pregnant or breastfeeding.
- Taking medications that interact with the study medication (MAO inhibitors, anticonvulsants, haloperidol, phenothiazines,selegiline, anesthetics
- Have other psychiatric diagnoses requiring therapy or medication.
- Physically dependent on opiates or alcohol.
- Currently being treated with bupropion hydrochloride (e.g. Zyban).
Key Trial Info
Start Date :
April 1 2001
Trial Type :
INTERVENTIONAL
End Date :
December 1 2005
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT00227812
Start Date
April 1 2001
End Date
December 1 2005
Last Update
January 12 2017
Active Locations (1)
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1
University of Texas Health Sci Cntr Houston
Houston, Texas, United States, 77030