Status:
COMPLETED
Relation of Obesity With Frequency of Meals (MST 0557)
Lead Sponsor:
Rockefeller University
Collaborating Sponsors:
Cornell University
Conditions:
Obesity
Insulin Resistance
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
The purpose of this study is to test the relationship between frequency of meals and hepatic fat content and insulin sensitivity. We, the researchers at Rockefeller University, hypothesize that low pl...
Detailed Description
The hypothesis will be tested by studying two groups of normal subjects who will receive a defined weight maintenance diet: one group will be given meals twice a day and other group will be given eigh...
Eligibility Criteria
Inclusion
- Healthy individuals
- Age between 18-45 years
- Body mass index (BMI) between 18.5 - 24.9
Exclusion
- Diabetes mellitus
- Chronic drug treatment for any medical condition like hypertension or hyperlipidemia, hyperthyroidism or taking weight control medications.
- Inability to give informed consent.
- Inability to give contact information including permanent residence or provide evidence of stable living environment for the study period.
- Active weight reduction of more than 7 pounds in the last 3 months.
- History of bleeding or blood clotting disorders.
- Pregnancy or breast-feeding in the women.
- History of anaphylaxis or anaphylactoid-like reaction as a result of food allergies.
- HIV or hepatitis B and C positive subjects.
- Subjects with hemoglobin \< 8.5 gm/dl.
- Abnormal liver function test (ALT, AST, alkaline phosphate, LDH, GGT or total bilirubin).
- Serum creatinine or BUN greater than the upper limit of the normal, serum albumin less than 3.5g/dl, or proteinuria 1+ or greater.
- History of alcohol intake of more than 40 g/day.
- Contraindications to magnetic resonance imaging (MRI) including pacemakers, surgical clips, metallic implants, neuromuscular- skeletal stimulators and internal orthopedic screws or rods.
Key Trial Info
Start Date :
March 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2009
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT00229255
Start Date
March 1 2005
End Date
June 1 2009
Last Update
June 1 2012
Active Locations (1)
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1
Rockefeller University Hospital
New York, New York, United States, 10021