Status:
COMPLETED
Research on the Nature, Diagnosis, and Treatment of Obesity and Diabetes
Lead Sponsor:
Rockefeller University
Conditions:
Insulin Resistance
Obesity
Eligibility:
All Genders
21-45 years
Brief Summary
The purpose of this study is to determine whether the level of FOXA2 expression in fat tissue is a biomarker of insulin resistance. To test this hypothesis, we will perform euglycemic-hyperinsulinemic...
Detailed Description
The investigators at Rockefeller University Hospital are engaged in research on the nature, diagnosis and treatment of obesity and diabetes. The investigators are trying to find out why insulin, a blo...
Eligibility Criteria
Inclusion
- Healthy individuals
- Age 21-45 years old
- BMI: either \< 25, or 30-35, or \> 40
- All patients must be willing and able to sign an informed consent form -
Exclusion
- Chronic illnesses other the than mild forms of illnesses related to obesity, such as hypertension, hyperlipidemia, and others, that do not require medical treatment
- Diabetes mellitus previously diagnosed as per subject report or an abnormal 2 hour OGTT at screening
- Chronic drug treatment for any medical condition
- Active weight reduction of more than 7 pounds in the last 3 months
- History of bleeding or blood clotting disorders
- Subjects with hemoglobin \<8.5 gm/dl
- Changes in smoking habits for the last 6 months
- Current pregnancy or current breast-feeding in women
- Allergic reaction to local anesthetics
- History of anaphylaxis or anaphylactic-like reactions
- Tendency to form scars (keloids) easily
- Irregular menses
- HIV and hepatitis B or C positive subjects -
Key Trial Info
Start Date :
September 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 1 2010
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT00229268
Start Date
September 1 2005
End Date
April 1 2010
Last Update
June 1 2012
Active Locations (1)
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1
Rockefeller University Hospital
New York, New York, United States, 10021