Status:
UNKNOWN
Functional and Molecular Characterisation of Oesophageal Distal Epithelium: Correlations With Acid and Non Acid Reflux
Lead Sponsor:
Nantes University Hospital
Conditions:
Gastroesophageal Reflux
Eligibility:
All Genders
18-70 years
Brief Summary
This study aims to characterize the permeability as well as some protein involved in the cell junction in the oesophageal epithelium in patients with GORD symptoms. In addition these patients will be ...
Detailed Description
This study aims to characterize the permeability as well as some protein involved in the cell junction in the oesophageal epithelium in patients with GORD symptoms. In addition these patients will be ...
Eligibility Criteria
Inclusion
- Main inclusion criteria :
- Digestive symptoms suggestive of GORD (heartburn, regurgitation, epigastric pain), or dyspeptic syndrome (nausea, belch, bloating, epigastric discomfort).
- Need of upper GI endoscopy and pH monitoring.
- Normal propagation of oesophageal persitaltic waves (manometry \< 6 months).
- Age 18 -70 yrs
- Signed informed consent
- Normal coagulation
Exclusion
- Barrett's oesophagus
- Previous oesophageal bleeding
- Need of NSAID treatment.
- Previous sus mesocolic surgery
- Alcool consumption \> 40g/d, smoking \> 10 cig/j
- Pregnancy or lack of contraceptive disposal, breast feeding.
- Allergy to Xylocaïne
Key Trial Info
Start Date :
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00231881
Last Update
April 30 2007
Active Locations (1)
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1
Nantes University Hospital
Nantes, France, 44093