Status:
COMPLETED
Vitamin D Deficiency: Bone Loss and Vascular Dysfunction
Lead Sponsor:
University of Kansas
Collaborating Sponsors:
National Osteoporosis Foundation
Conditions:
Postmenopausal Women
Eligibility:
FEMALE
50-90 years
Phase:
NA
Brief Summary
To learn if there is a connection between low vitamin D level and hardening of the arteries.
Detailed Description
Osteoporosis and vascular disease are two of the most common disorders affecting postmenopausal women. A potential association, beyond aging, has long been speculated. Our previous study revealed evid...
Eligibility Criteria
Inclusion
- Females ages 50-70 with ability to give informed consent
- One year past last menstrual period
- 20 women with Vitamin D levels \< 15 mg/ml
- 20 women with Vitamin D levels \> 30 mg/ml
Exclusion
- women receiving hormone replacement therapy
- women receiving medication known to effect vascular compliance, including anti-hypertension medications
- subjects receiving therapy for osteoporosis
- hyperthyroidism
- untreated hypothyroidism
- history of metabolic bone disease
- current or previous use of medications known to accelerate bone loss
- chronic liver disease
- chronic renal disease
- diabetes mellitus
- obesity, BMI \> 24
Key Trial Info
Start Date :
April 1 2004
Trial Type :
INTERVENTIONAL
End Date :
September 1 2007
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00235586
Start Date
April 1 2004
End Date
September 1 2007
Last Update
September 20 2007
Active Locations (1)
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1
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160