Status:
COMPLETED
D-Serine for Enhancing Cognitive Retraining for the Treatment of Schizophrenia
Lead Sponsor:
Yale University
Collaborating Sponsors:
Stanley Medical Research Institute
Donaghue Foundation
Conditions:
Schizophrenia
Schizoaffective Disorder
Eligibility:
All Genders
18-65 years
Phase:
PHASE3
Brief Summary
This study will examine the effectiveness of D-serine in increasing and sustaining the benefits of cognitive retraining in people with schizophrenia.
Detailed Description
This study is based on the hypothesis that by increasing NMDA receptor function in the brain and thereby increasing the capacity of the brain to both form new connections and strengthen existing conne...
Eligibility Criteria
Inclusion
- Diagnosis of schizophrenia or schizoaffective disorder
- Clinically stable
- Treated with antipsychotic medications for at least 6 months in the past, and on a stable dose of the same antipsychotic medication over the past month
- Not pregnant or lactating
Exclusion
- Other current or past DSM-IV Axis I diagnosis
- Calgary Depression scale score \>10 or Simpson-Angus Rating Scale score \> 20
- Currently treated with clozapine, lamotrigine or carbamazepine, or defined as treatment refractory
- Substance abuse or dependence within the past 3 months, except for nicotine
- Wechsler Adult Intelligence Scale-Revised score \< 70
- Significant recent (within past 3 months) risk of committing suicide
- Abnormal thyroid function tests within the last 6 months
- Previous treatment with D-serine
- History of evidence of a medical or neurological condition that would expose the subject to an undue risk of a significant adverse event or interfere with assessments of safety or efficacy during the trial
- Clinically significant abnormal laboratory test results at screening
- ECT treatment within the past two months
Key Trial Info
Start Date :
February 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT00237848
Start Date
February 1 2005
Last Update
June 18 2012
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
National Institute of Mental Health and Neurosciences
Bangalore, Karnataka, India, 560029