Status:
COMPLETED
Effect of CPAP (Continuous Positive Airway Pressure) on Lung Function in Asthmatics With Sleep Apnea
Lead Sponsor:
National Jewish Health
Conditions:
Asthma
Sleep Apnea
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This is a research study of asthma and sleep apnea. Our hypothesis is that untreated sleep apnea causes inflammation in the lung, which can worsen asthma. We believe treatment of sleep apnea will redu...
Eligibility Criteria
Inclusion
- Adult (\>18yrs at the time of recruitment)
- Body mass index (BMI) ≥ 30
- Symptoms suggestive of sleep apnea
- Epworth Sleepiness Score (ESS) within range
- Positive sleep study for sleep apnea
Exclusion
- Tobacco use within the last 3 months.
- Presence of other significant comorbid heart or lung disease
- Presence of another chronic inflammatory disease, such as connective-tissue disease, inflammatory bowel disease, or active infection.
- Use of systemic steroids, as defined as any prednisone use in the preceding 3 months.
- Use of leukotriene antagonists or theophylline within the preceding 6 weeks.
- Presence of severe or uncontrolled sinusitis, such that CPAP therapy will be difficult or uncomfortable.
- History of significant claustrophobia, uncontrolled psychiatric disease, or anticipated intolerance of CPAP therapy.
- Night shift workers, or other subjects with significantly altered sleep-wake cycles.
- Baseline post-bronchodilator FEV1 \< 70% predicted.
- Severe gastroesophageal reflux disease.
Key Trial Info
Start Date :
December 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2005
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00238069
Start Date
December 1 2004
End Date
August 1 2005
Last Update
March 29 2017
Active Locations (1)
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1
National Jewish Medical and Research Center
Denver, Colorado, United States, 80206