Status:
COMPLETED
Effect of Prevacid on Prostaglandin Levels in Patient With Stress Ulcer
Lead Sponsor:
Emory University
Collaborating Sponsors:
TAP Pharmaceutical Products Inc.
Conditions:
Stomach Ulcer
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to measure the prostaglandin levels in patients with stress ulcer and the effect of Prevacid on prostaglandin levels in patients with stress ulcer.
Detailed Description
The prostaglandin system plays an important role in the gastric mucosa to strengthen its resistance against injury. Critically ill patients are at greatest risk of developing stress-related gastric mu...
Eligibility Criteria
Inclusion
- Patients in ICU with documented gastric stress ulcer by endoscopic examination, including patients with H. Pylori infection;
- Patients have no known ulcer within 8 weeks prior to be admitted to ICU;
- Patients not on any PPI for 4 weeks prior to the study;
- Patients or family be consented for the study.
Exclusion
- Patients have gastric ulcer within 8 weeks prior to be admitted to ICU;
- Patients have gastric cancer confirmed by pathology;
- Patients on one of the PPIs already;
- Patients on any of the Non-steroidal Antiinflammatory Drugs.
Key Trial Info
Start Date :
October 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2007
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00239551
Start Date
October 1 2005
End Date
December 1 2007
Last Update
July 31 2013
Active Locations (1)
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1
Emory University School of Medicine
Atlanta, Georgia, United States, 30322