Status:
COMPLETED
Nitric Oxide Administration for Acute Respiratory Distress Syndrome
Lead Sponsor:
Children's Hospital of Philadelphia
Collaborating Sponsors:
Mallinckrodt
Conditions:
Acute Respiratory Distress Syndrome
Eligibility:
All Genders
1-18 years
Phase:
PHASE3
Brief Summary
This research project is an open-label, randomized study for the use of Nitric Oxide in pediatric patients with acute respiratory distress syndrome (ARDS). The study examines whether nitric oxide (NO)...
Detailed Description
At low concentrations, nitric oxide(NO) functions as a cellular messenger and regulator of microcirculation. NO may have an important role in the pathogenesis of ARDS as well as its treatment. NO may ...
Eligibility Criteria
Inclusion
- Patient is intubated and mechanically ventilated in the Pediatric Intensive Care Unit with a PaO2/FiO2 ratio less than or equal to 100, FiO2 greater than or equal to 0.60, PEEP greater than or equal to 10, and a Murray score greater than or equal to 2.5.
Exclusion
- Neonates (1 week to 28 days) and/or patients on extracorporeal membrane oxygenation
Key Trial Info
Start Date :
September 1 2000
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2008
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT00240487
Start Date
September 1 2000
End Date
September 1 2008
Last Update
April 24 2015
Active Locations (1)
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1
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104